Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation |
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| Authors: | Masahito Suiko Katsuhisa Kurogi Takuyu Hashiguchi Yoichi Sakakibara Ming-Cheh Liu |
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| Institution: | 1. Faculty of Agriculture, Department of Biochemistry and Applied Biosciences, University of Miyazaki, Miyazaki, Japan;2. Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, USA;3. Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, USA |
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| Abstract: | The cytosolic sulfotransferases (SULTs) are Phase II detoxifying enzymes that mediate the sulfate conjugation of numerous xenobiotic molecules. While the research on the SULTs has lagged behind the research on Phase I cytochrome P-450 enzymes and other Phase II conjugating enzymes, it has gained more momentum in recent years. This review aims to summarize information obtained in several fronts of the research on the SULTs, including the range of the SULTs in different life forms, concerted actions of the SULTs and other Phase II enzymes, insights into the structure–function relationships of the SULTs, regulation of SULT expression and activity, developmental expression of SULTs, as well as the use of a zebrafish model for studying the developmental pharmacology/toxicology. |
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| Keywords: | sulfotransferase 3′-phosphoadenosine-5′-phosphosulfate Phase II detoxifying enzymes |
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