Cerebrovascular gene linked to Alzheimer's disease pathology |
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Authors: | de la Torre Jack C |
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Affiliation: | Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA. jcdelatorre@comcast.net |
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Abstract: | There is already considerable evidence from epidemiological, pathological and clinical reports that vascular factors are crucial in the pathogenesis of Alzheimer's disease (AD). Cerebral hypoperfusion has been shown to be a preclinical condition and a most accurate indicator for predicting whether people will develop AD. Now, a new study by Zlokovic and colleagues reveals that the vascular gene MEOX2 has a low expression in cultured brain endothelial cells from AD patients. This, together with evidence linking a dysfunctional cerebrovasculature to the pathogenesis of AD, suggests that the homeobox gene MEOX2 downregulation provides a therapeutic target to AD and a better understanding of this disorder. |
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