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The effect of propargylic substitution on the activation and aromatization of enediynes |
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| Authors: | Mark D. Wittman John F. Kadow Kahnie Pham Leung Kinwa Harold A. Mastalerz Dolatrai M. Vyas William C. Rose Wyle Solomon Nada Zein |
| Affiliation: | a Bristol-Myers Squibb Pharmaceutical Research Institute Division of Chemistry, 5 Research Pkwy, Wallingford, CT 06492-7660 U.S.A. b Bristol-Myers Squibb Pharmaceutical Research Institute Oncology Drug Discovery, P.O. Box 4000, Princeton, NJ 08543-4000 U.S.A. |
| Abstract: | The thiol activation and aromatization of bicyclo[7.1.0]enediynes was found to be dependent of the nature of the propargyl substituent. These effects are correlated to antitumor activity. |
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