Identification of calcium-binding proteins associated with the lymphocyte plasma membrane |
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Authors: | A A Davies M J Crumpton |
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Affiliation: | Department of Pharmacology University of Minnesota, School of Medicine Minneapolis, Minnesota 55455, USA |
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Abstract: | The Nonidet P40 insoluble fraction of lymphocyte plasma membrane contains three polypeptides of about 68,000-, 33,000- and 28,000-Mr which are solubilised by Ca2+-chelators. As judged by various criteria the 33,000-Mr polypeptide is homologous to the 36,000-Mr pp60src kinase substrate of chicken fibroblasts and the 68,000-Mr polypeptide is related to the 67,000-Mr "calelectrin" of bovine liver. The 28,000-Mr polypeptide may also be related to calelectrin. |
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