|
|||||
|
|
Identification of eleven human hemoglobin variants by high-performance liquid chromatography: Additional data on functional properties and clinical expression |
|
| Authors: | W A Schroeder Joan B Shelton J Roger Shelton Darleen Powars Shlomo Friedman James Baker Jerry Z Finklestein B Miller Cage S Johnson J R Sharpsteen Lance Sieger Eric Kawaoka |
| Institution: | (1) Division of Chemistry and Chemical Engineering, California Institute of Technology, 91125 Pasadena, California;(2) Department of Pediatrics, University of Southern California School of Medicine, 90033 Los Angeles, California;(3) Methodist Central Hospital, 75265 Dallas, Texas;(4) Department of Pediatrics and Pathology, Memorial Hospital of Long Beach, 90801 Long Beach, California;(5) Department of Medicine, University of Southern California School of Medicine, 90033 Los Angeles, California;(6) Southern California Permanente Medical Group, 90710 Harbor City, California;(7) Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, 90509 Torrance, California |
| Abstract: | Eleven abnormal hemoglobins were detected in the course of cord blood screening or in the evaluation of evident hematological problems in individual cases. Identification of the variant in each case was done by high-performance liquid chromatography (HPLC); HPLC provides a rapid, sensitive means for the examination of abnormal hemoglobins. Some of the 11 variants that were identified have been described repeatedly and are included to provide information on the HPLC behavior of tryptic peptides. Others are much rarer. Additional information is provided about the hematological and clinical expression as well as ethnic and geographical distribution of the abnormal hemoglobin.This investigation was supported in part by Grants HL-02558 and HL-15162 from the National Institutes of Health, U.S. Public Health Service. |
| Keywords: | high-performance liquid chromatography human hemoglobin variants |
| 本文献已被 SpringerLink 等数据库收录！ | |