Localization of the human HuR gene to chromosome 19p13.2 |
| |
| Authors: | Wei-Jun Ma H Furneaux |
| |
| Institution: | (1) Program in Molecular Pharmacology and Therapeutics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA Tel.: +1-212-639-8701; Fax: +1-212-639-2861 e-mail h-furneaux@ski.mskcc.org, US |
| |
| Abstract: | The HuR gene encodes a specific RNA binding protein that is a member of the human Elav-like gene family. This family of proteins,
which includes HuD, HuC and Hel-N1, is involved in cellular differentiation. Alterations of HuD and Hel-N1 structure are associated
with small cell lung tumors and medulloblastomas. To investigate a possible linkage of the HuR gene to malignancy, the locus
of the gene was mapped on human metaphase chromosomes. Analysis of the fluorescence signals on banded chromosomes showed that
the HuR gene is localized to human chromosome 19p13.2.
Received: 6 June 1996 / Revised: 8 August 1996 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
