Solid-phase synthesis of oligonucleotides labeled with luminescent lanthanide(III) chelates |
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Authors: | Jaakkola Lassi Peuralahti Jari Hakala Harri Kunttu Jenni Tallqvist Pekka Mukkala Veli-Matti Ylikoski Alice Hovinen Jari |
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Institution: | PerkinElmer Life and Analytical Sciences, Wallac Oy, P.O. Box 10, FIN-20101 Turku, Finland. |
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Abstract: | The synthesis of phosphoramidite building blocks that allow introduction of luminescent europium(III), terbium(III), dysprosium(III), and samarium(III) chelates to oligonucleotides on the solid phase is described. Several labeled oligonucleotides using these building blocks were prepared, and the photophysical properties of these bioconjugates were investigated. |
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