Activation of protein kinase C is essential for sustained insulin secretion in response to cholinergic stimulation |
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Authors: | S J Persaud P M Jones S L Howell |
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Institution: | Biomedical Sciences Division, King's College London, Kensington, U.K. |
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Abstract: | Insulin secretion from isolated rat islets of Langerhans is enhanced by cholinergic agonists, such as carbachol (CCh), in the presence of a stimulatory concentration of glucose. Depletion of islet protein kinase C activity by prolonged exposure to a tumour-promoting phorbol ester did not prevent the initial secretory response to CCh, but markedly reduced the duration of CCh-induced elevated secretory rates. These results suggest that the major action of PKC is in maintaining rather than initiating the insulin secretory response to cholinergic agonists. |
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