| 致命鹅膏菌毒素对DMBA/巴豆油诱导小鼠皮肤肿瘤的治疗作用 |
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| 引用本文： | 舒畅,陶文沂,周荼.致命鹅膏菌毒素对DMBA/巴豆油诱导小鼠皮肤肿瘤的治疗作用[J].菌物学报,2007,26(2):284-288. |
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| 作者姓名： | 舒畅 陶文沂 周荼 |
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| 作者单位： | 江南大学生物工程学院生物制药实验室,无锡,214122;江南大学工业生物技术教育部重点实验室,无锡,214122 |
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| 摘 要： | 研究了致命鹅膏中的毒素在安全剂量下抑制小鼠皮肤肿瘤的效果,并对此毒素的药用安全性进行初步评价。采用经典的DMBA/巴豆油诱导小鼠皮肤乳头状瘤形成的二阶段致癌模型,观察和评价致命鹅膏毒素在不同剂量下抑制肿瘤的效果,并且通过测定血清中氨基己糖的含量来判断对肝损伤的情况。结果表明,致命鹅膏毒素在某一低剂量下对DMBA/巴豆油诱导小鼠皮肤乳头状瘤有较好的治愈效果,且对小鼠肝脏无损伤,证明了致命鹅膏毒素可以较好地治疗皮肤癌。
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| 关 键 词： | 致命鹅膏 皮肤肿瘤 治疗 氨基己糖 |
| 文章编号： | 1672-6472（2007）02-0284-0288 |
| 收稿时间： | 2006-11-28 |
| 修稿时间： | 2006-11-282007-02-13 |
The effects of Amanita exitialis toxin on the cure of mouse skin papillomas chemically induced by DMBA/ croton oil |
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| Authors: | SHU Chang TAO Wen-Yi and ZHOU Tu |
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| Institution: | (1.Biopharmaceutical Laboratory, School of Biotechnology, Southern Yangtze University, Wuxi 214122);(2.Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214122);(1.Biopharmaceutical Laboratory, School of Biotechnology, Southern Yangtze University, Wuxi 214122);(2.Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214122);(1.Biopharmaceutical Laboratory, School of Biotechnology, Southern Yangtze University, Wuxi 214122);(2.Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214122) |
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| Abstract: | Inhibition effect of the toxin in Amanita exitialis on mouse skin papillomas under safe dose and the drug safety was evaluated primarily.The mouse skin papilloma model was established by 7,12-dimethylbenz(a) anthraene(DMBA)/croton oil induction,which was a classical two-stage cancer model.The inhibition effect of Amanita exitialis toxin was observed and evaluated under different doses.By means of analysis of amino-hexose in serum,the hepatic celt damage induced by toxin was determined.The result showed that Amanita exitialis toxin in tow dose can cure skin tumor in dose-dependent manner,and no harmful effect for hepatic cell.It was concluded that Amanita exitialis toxin can cure skin cancer. |
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| Keywords: | Amanita exitialis skin papilloma cure amino-hexose |
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