Characterization of human stellate cell activation-associated protein and its expression in human liver |
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| Authors: | Asahina Kinji Kawada Norifumi Kristensen Dan Bach Nakatani Kazuki Seki Shuichi Shiokawa Miho Tateno Chise Obara Masanobu Yoshizato Katsutoshi |
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| Affiliation: | Tissue Regeneration Project, Hiroshima Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Corporation, Japan. |
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| Abstract: | This study cloned cDNA of human homologue (hSTAP) of rat stellate cell activation-associated protein (rSTAP). hSTAP gene is on chromosome 17q and is composed of four exons. Various types of cells including hepatic stellate cells expressed hSTAP mRNA. Recombinant hSTAP was a heme protein with the activity of peroxidase. hSTAP can be used as a marker of quiescent stellate cells in human liver. |
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