Macrophage Functional Heterogeneity in the in vitro Induced Immune Response |
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Authors: | WILLIAM S. WALKER |
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Affiliation: | 1.Department of Immunology, Public Health Research Institute,City of New York, Inc.,New York |
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Abstract: | RNA from antigenically stimulated peritoneal macrophages is immunogenic in vitro1–4. The studies of Fishman and Adler5–6 suggest that the peritoneal macrophage population consists of at least three functionally distinct subpopulations. Although most peritoneal macrophages act as scavenger cells7, a second population—possibly less than one cell per 1,000—consists of cells that produce but do not necessarily secrete antibody8,9 and respond to antigen by synthesizing informational RNA. On transfer to normal lymphoid cells, this RNA elicits IgM antibody with the allotypic specificity of the macrophage donor10. A third type of macrophage gives rise to the RNA-antigen complex responsible for the in vitro synthesis of IgG antibody with the allotypic specificity of the lymphocyte donor10. |
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