Hypomelanosis of Ito: involvement of chromosome aberrations in this syndrome |
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| Authors: | E Lenzini P Bertoli L Artifoni P A Battistella C Baccichetti A Peserico |
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| Affiliation: | Servizio di Genetica Medica, Dipartimento di Pediatria, Università di Padova, Italy. |
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| Abstract: | The authors report on cytogenetic results of six patients with hypomelanosis of Ito. Karyotypes from peripheral lymphocytes prometaphases and skin fibroblasts metaphases were normal. A review of the literature revealed no specific chromosomal abnormality but a close association between mosaicism and HI syndrome. The X-chromosome was involved in 53% of the abnormal cases. |
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