The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries |
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Authors: | Sylvie E. Blondelle Ema Takahashi Kim Thy Dinh R.A. Houghten |
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Affiliation: | Torrey Pines Institute for Molecular Studies, San Diego, CA, USA |
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Abstract: | S.E. BLONDELLE, E. TAKAHASHI, K.T. DINH AND R.A. HOUGHTEN. 1995. A series of peptides identified through the use of synthetic hexapeptide combinatorial libraries (represented by the formula Ac-RRWWCO-NH2) were examined for their antimicrobial activity against five different micro-organisms. Their toxicity was also evaluated in an in vitro haemolytic assay. The peptides showed activity against the five micro-organisms, although higher activities were found against Gram-positive bacteria. Both growth inhibition and cell viability assays were carried out to demonstrate the bactericidal activities of these peptides against two of the micro-organisms tested. The dimeric cystine forms of these peptides were shown to have biological activities identical to the monomeric forms. |
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