| nc2Cancer:一个研究与癌症相关人类非编码RNA的数据库 |
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| 引用本文： | 程卓,刘珂,严章明,向书念,孙之荣. nc2Cancer:一个研究与癌症相关人类非编码RNA的数据库[J]. 生物信息学, 2015, 13(2): 77-81 |
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| 作者姓名： | 程卓 刘珂 严章明 向书念 孙之荣 |
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| 作者单位： | 清华大学生命科学学院教育部生物信息学重点实验室,北京 100084,清华大学生命科学学院教育部生物信息学重点实验室,北京 100084,清华大学生命科学学院教育部生物信息学重点实验室,北京 100084,清华大学生命科学学院教育部生物信息学重点实验室,北京 100084,清华大学生命科学学院教育部生物信息学重点实验室,北京 100084 |
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| 基金项目： | 国家 973 计划 (No. 2012CB925203) ,国家自然科学基金(No.31171274)。 |
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| 摘 要： | 伴随着高通量测序技术的飞速发展,许多新型的非编码RNA陆续被发现,比如长链非编码RNA(lncRNA)和环状RNA(Circular RNA)。先前的研究已经表明这些非编码RNA在基因表达调控过程中起着很重要的作用,并且与癌症的发生有着很密切的联系。但是,由于研究者们仍然对它们行使何种功能知之甚少,鉴定这些非编码RNA是否与人类癌症存在密切的相互关系仍然是一个巨大的挑战。为了促进这一领域的研究,这篇文章的作者分析了大规模的RNA相互作用数据,然后建立了数据库nc2Cancer(http://www.bioinfo.tsinghua.edu.cn/nc2Cancer/index.php)。这个数据库的目标便是提供非编码RNA与癌症之间的全面关系。现在,该nc2Cancer数据库包括了三种类型的非编码RNA分子:长链非编码RNA,环状RNA以及由假基因转录而成的RNA。这项研究将有助于研究者更好地去理解非编码RNA的功能以及它们在人类癌症发生过程中所起到的作用。
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| 关 键 词： | 非编码RNA 癌症 MicroRNA RNA相互作用网络 |
| 收稿时间： | 2015-03-31 |
| 修稿时间： | 2015-04-14 |
nc2Cancer: a database for cancer-associated human ncRNAs |
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| CHENG Zhuo,LIU Ke,YAN Zhangming,XIANG Shunian and SUN Zhirong. nc2Cancer: a database for cancer-associated human ncRNAs[J]. Chinese Journal of Bioinformatics, 2015, 13(2): 77-81 |
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| Authors: | CHENG Zhuo LIU Ke YAN Zhangming XIANG Shunian SUN Zhirong |
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| Affiliation: | MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China,MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China,MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China,MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China and MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China |
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| Abstract: | With the rapid development of high-throughput sequencing technology, many new types of non-coding RNAs (such as lncRNAs and circular RNAs) have been identified. Previous studies have shown that these non-coding RNAs play critical roles in gene regulation and have strong associations with cancers. However, since we know little on how the ncRNAs excute their functions, it remains a challenge for us to fully identify the associations between ncRNAs and human cancer. To facilitate the study of this field, we analyzed large-scale RNA-RNA interaction data and constructed a database named nc2Cancer(http://www.bioinfo.tsinghua.edu.cn/nc2Cancer/index.php), a web resource which aims to provide comprehensive associations between ncRNAs and cancer. Currently, nc2Cancer covers three types of non-coding RNAs (lncRNAs, circular RNAs and RNAs transcribed from pseudogenes). This study will greatly expand the understanding of ncRNA functions and their possible roles in cancer development. |
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| Keywords: | ncRNA Cancer microRNA RNA-RNA network |
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