Consumption of a high-fat-high-sucrose diet partly diminishes mechanical and structural adaptations of cardiac muscle following resistance training |
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| Authors: | Kevin Boldt Stela Mattiello Venus Joumaa Jeannine Turnbull Paul WM Fedak Walter Herzog |
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| Institution: | 1.Human Performance Laboratory, University of Calgary, Calgary, Canada; 2.Department of Physical Therapy, Center of Biological and Health Sciences, Federal University of São Carlos, São Carlos, Brazil; 3.Health Centre, Federal University of Santa Catarina, Florianopolis, Brazil; 4.Department of Cardiac Sciences, University of Calgary, Calgary, Canada |
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| Abstract: | Purpose]The purpose of this study was to investigate the effects of a high-fat high-sucrose (HFHS) diet on previously reported adaptations of cardiac morphological and contractile properties to resistance training.Methods]Twelve-week-old rats participated in 12-weeks of resistance exercise training and consumed an HFHS diet. Echocardiography and skinned cardiac muscle fiber bundle testing were performed to determine the structural and mechanical adaptations.Results]Compared to chow-fed sedentary animals, both HFHS- and chow-fed resistance-trained animals had thicker left ventricular walls. Isolated trabecular fiber bundles from chow-fed resistance-trained animals had greater force output, shortening velocities, and calcium sensitivities than those of chow-fed sedentary controls. However, trabeculae from the HFHS resistance-trained animals had greater force output but no change in unloaded shortening velocity or calcium sensitivity than those of the chow-fed sedentary group animals.Conclusion]Resistance exercise training led to positive structural and mechanical adaptations of the heart, which were partly offset by the HFHS diet. |
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| Keywords: | obesity high-fat high-sucrose diet cardiac adaptations resistance exercise skinned fibers echocardiography |
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