Abietane diterpenoids from Clerodendrum mandarinorum |
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| Institution: | 1. Department of Biology, University of Science and Technology of China, Hefei, 230026, China;2. Department of Natural Pharmaceutical Chemistry, China Pharmaceutical University, Nanjing, 210009, China;3. Shanghai Institute of Pharmacy, Shanghai, 200031, China;4. Gifu Prefectural Institute of Health and Environment, 4-6-3 Noishiki, Gifu, 500-8226, Japan;1. Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan, ROC;2. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan, ROC;3. Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan, ROC;4. School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan, ROC;5. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan, ROC;6. Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan, ROC;7. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC;8. Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan, ROC;9. Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan, ROC;10. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan, ROC;1. Rehabilitation Center, First Affiliated Hospital of Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi Province, China;2. Department of Dermatology, the 451st Hospital of People’s Liberation Army, Xi’an 710054, Shaanxi Province, China;1. Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China;2. School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang, 318000, PR China;3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, PR China;1. Ecological Society of Shandong, Shandong Institute of Environmental Science, Jinan 250012, China;2. School of Pharmaceutical Sciences, Shandong University, Jinan, China;1. Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala, Col. Santo Tomás, México, D.F. 11340, Mexico;2. Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, km 4.5 Carretera Pachuca-Tulancingo, Mineral de la Reforma, Hidalgo 42184, Mexico;3. Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado 14-740, México, D.F. 07000, Mexico;1. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China;2. Research and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu, 610066, China;3. Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Jiangmen, China;4. International Healthcare Innovation Institute (Jiangmen), Jiangmen, 529040, China |
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| Abstract: | From the stem of Clerodendrum mandarinorum Diels (Verbenaceae), three new abietane derivatives, mandarones A, B and C, have been isolated. The structures were characterized as (5R,10S)-12-hydroxy-8,11,13-abietatriene-37-dione (mandarone A), (16 S)-12,16-epoxy-11,14-dihydroxy-17(15→16)-abeo-abieta-5,8,11,13-tetraene-7-one (mandarone B) and 12,16-epoxy-11,14-dihydroxy-17(15→16)-abeo-abieta-2,5,8,11,13,15-hexaene-7-one (mandarone C) on the basis of spectral analysis. Mandarones B and C possess a rearranged abietane skeleton which contains a 17(15→16)-abeo-abietane framework. |
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