|
|||||
|
|
Structure and function of molybdopterin containing enzymes |
|
| Authors: | Maria Jo o Rom o, J rg Kn blein, Robert Huber,Jos J. G. Moura |
| Affiliation: | b Instituto de Tecnologia Química e Biológica, Apartado 127, 2780 Oeiras and Instituto Superior Técnico, Departamento de Química, 1096 Lisboa Codex, Portugal c Max-Planck-Institut für Biochemie, am Klopferspitz 18a, D-82152 Martinsried, Germany d Departamento de Química (and Centro de Química Fina e Biotecnologia), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2825 Monte de Caparica, Portugal |
| Abstract: | Molybdopterin containing enzymes are present in a wide range of living systems and have been known for several decades. However, only in the past two years have the first crystal structures been reported for this type of enzyme. This has represented a major breakthrough in this field. The enzymes share common structural features, but reveal different polypeptide folding topologies. In this review we give an account of the related spectroscopic information and the crystallographic results, with emphasis on structure-function studies. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |