FoxP3 genetic variants and risk of non-small cell lung cancer in the Chinese Han population |
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Authors: | Yan-Qi He Qiao Bo Wei Yong Zhi-Xin Qiu Ya-Lun Li Wei-Min Li |
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Affiliation: | 1. Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China;2. Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;3. Department of General Surgery, The Seventh People''s Hospital of Chengdu, Chengdu 610021, China |
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Abstract: | CD4+CD25+ regulatory T cell-mediated immunosuppression is one of the crucial mechanisms that tumor cells use to evade the immune system. The forkhead box P3 (FoxP3) gene regulates regulatory T-cell development and function and may modulate the susceptibility to non-small cell lung cancer (NSCLC). Because a single nucleotide polymorphism (SNP) within the FoxP3 gene (rs3761548 in the promoter region) is associated with susceptibility to Graves' disease, this study detected rs3761548 in a hospital-based case–control study. A total of 192 NSCLC patients and 259 healthy subjects were recruited for the polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis of FoxP3 SNP. The data showed that the A allele of rs3761548 significantly increased NSCLC risk (P = 0.000, OR = 2.32, 95%CI = 1.736–3.102). The AC genotype, AA genotype, and the combined A variant genotype (AA + AC) were also associated with a higher risk of NSCLC (OR [95%CI] = 2.147[1.419–3.247], 4.413[2.359–8.255], and 2.563[1.746–3.761], respectively). Moreover, a significantly higher frequency of AA + AC genotype was observed in patients with stage II NSCLC (OR, 2.053; 95%CI, 1.033–4.078). In conclusion, the data from the current study demonstrated for the first time the association of the FoxP3 SNP with a risk of developing NSCLC in the Chinese Han population. |
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Keywords: | FoxP3, forkhead box P3 NSCLC, non-small cell lung cancer SNP, single nucleotide polymorphism PCR-RFLP, polymerase chain reaction&ndash restriction fragment length polymorphism SCC, squamous cell carcinoma Tregs, regulatory T cells OR, odds ratio CI, confidence intervals |
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