Association between MDR1 C3435T polymorphism and risk of breast cancer |
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| Authors: | Zhaoming Wang Ting Wang Jianmin Bian |
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| Affiliation: | 1. The First Clinical Medical College, Nanjing Medical University, Nanjing, China;2. School of Public Health, Nanjing Medical University, Nanjing, China;3. Department of General Surgery, The Affiliated Nanjing First Hospital of Nanjing Medical University, Nanjing, China |
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| Abstract: | The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to the carcinogenesis. Many published studies have evaluated the association between the MDR1 C3435T polymorphism and breast cancer risk. However, the results remain conflicting rather than conclusive. To derive a more precise estimation of the association between MDR1 C3435T polymorphism and risk of breast cancer, we performed a meta-analysis comprised of 10 case–control studies, including 5282 breast cancer cases and 7703 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the association. The overall results indicated that the variant genotypes were associated with a significantly increased risk of breast cancer (TT versus CC: OR = 1.45, 95% CI = 1.14–1.30, TT versus CT/CC: OR = 1.13, 95% CI = 1.04–1.23, TT/CT versus CC: OR = 1.22, 95% CI = 1.02–1.46). Our results suggest that the MDR1 C3435T polymorphism may contribute to individual susceptibility to breast cancer. |
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| Keywords: | ABCB1, ATP-binding cassette sub-family B gene 1 ATP, adenosine triphosphate CI, confidence intervals HWE, Hardy&ndash Weinberg equilibrium MALDI-TOF MS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry MDR, multi-drug resistance MDR1, multi-drug resistance gene 1 OR, odds ratio PCR, polymerase chain reaction PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism P-gp, P-glycoprotein SNP, single-nucleotide polymorphism TP53, tumor protein gene 53 |
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