Chronic administration of lithium modulates tryptophan transport by changing the properties of the synaptosomal plasma membrane |
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| Authors: | E Herrero C Giménez M C Aragón |
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| Institution: | 1. Metabolic Psychiatry, Dept. of Psychiatry and Behavioral Sciences, Stanford Medicine, Stanford, CA, USA;2. Department of Medicine, Duke University Medical Center, Durham, NC, USA;3. Department of Pediatrics and Medicine, University of California-San Francisco, San Francisco, CA, USA;4. Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, MI, USA;1. Allan Gray Centre for Leadership Ethics, Philosophy Department, Rhodes University, PO Box 94, Grahamstown 6140, South Africa;2. Community Engagement Division, Rhodes University, Grahamstown, South Africa;3. Critical Studies in Sexualities and Reproduction, Psychology Department, Rhodes University, Grahamstown, South Africa;1. Department of Pathology, University of Iowa, Iowa City, IA 52242, USA;2. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA |
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| Abstract: | The effect of chronic administration of lithium salts on the sodium dependent high-affinity system for tryptophan uptake was examined in plasma membrane vesicles derived from rat brain. Tryptophan transport was measured as a function of the temperature, Arrhenius plots of the data were prepared, and the apparent energies of activation were computed. Both plots were biphasic, the transition temperature decreasing from 23 degrees C in control animals to 18 degrees C in treated rats. The average apparent energies of activation for the carrier also change -both below and above the transition temperature- in treated animals when compared to controls. Our data support the idea that chronic administration of lithium induces a more fluid state of the synaptosomal plasma membrane that could explain many of the effects of Li+ on membrane-bound proteins. |
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