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Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens |
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| Authors: | Farooqui Akhlaq A Rapoport Stanley I Horrocks Lloyd A |
| Institution: | (1) Department of Medical Biochemistry, The Ohio State University, Columbus, Ohio, 43210;(2) Laboratory of Neurosciences, National Institute on Aging, Building 10, Room 6C103, Bethesda, Maryland, 20892 |
| Abstract: | The ethanolamine plasmalogens are decreased whereas serine glycerophospholipids are significantly increased in plasma membrane phospholipid in affected regions of brain in Alzheimer's disease. This may be due to stimulation of Ca2+-independent plasmalogen-selective phospholipase A2, which was recently discovered in brain. This phospholipase A2 differs from other Ca2+-independent phospholipases A2 in response to ATP and various inhibitors. It may be responsible for excess release of arachidonic acid and accumulation of prostaglandins and lipid peroxides in AD. Accumulation of the above lipid metabolites due to abnormal receptor function and signal transduction may contribute to neurodegeneration in AD. |
| Keywords: | Plasmalogens phospholipase A2 lipid peroxidation plasma membrane signal transduction neurodegradation Alzheimer's disease |
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