The effect of different high-pass filter settings on peak latencies in the event-related potentials of schizophrenics,patients with Parkinson's disease and controls |
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| Institution: | 1. Institute of Neurology, Madras Medical College, Chennai, India;2. Lalitha Superspecialty Hospital, Kothapet, Guntur, India;1. Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Cagliari, Italy;2. Multiple Sclerosis Centre, Binaghi Hospital, Department of Medical Sciences and Public Health, University of Cagliari, Italy;3. Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy;1. IRCCS Centro Neurolesi “Bonino Pulejo”, Messina, Italy;2. Regional Epilepsy Centre “Bianchi Melacrino Morelli” Hospital, Reggio, Calabria, Italy;3. Department of Experimental Medicine, Section of Human Physiology and Centro Polifunzionale di Scienze Motorie, University of Genoa, Italy;4. Department of Neuroscience, University of Messina, Italy;5. Department of Clinical and Experimental Medicine, University of Messina, Italy;6. Department of Physiology, Pharmacology and Neuroscience, City University of New-York, Medical School, New York, USA;1. IRCCS Casa Sollievo della Sofferenza Research Hospital, Huntington and Rare Diseases Unit, Viale Regina Margherita, 261, 00198, Rome, Italy;2. Department of Biotechnological and Applied Clinical Sciences, University of L''Aquila, Italy;3. Institute of Cognitive Sciences and Technologies (ISTC) - National Research Council (CNR), Rome, Italy;4. S. Anna Institute and Research in Advanced Neurorehabilitation (RAN), Crotone, Italy;5. Research Center for Motor Control and Neuroplasticity, KU Leuven, Leuven, Belgium;6. Department of Information Engineering Università Politecnica delle Marche, Ancona, Italy;7. Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, United States;8. Service of Medical Statistics & Information Technology, Fondazione Fatebenefratelli per la Ricerca e la Formazione Sanitaria e Sociale, Lungotevere de'' Cenci 5, 00186, Rome, Italy;9. Department of Neuroscience, Policlinico ‘Tor Vergata’, Rome, Italy;10. Azienda ULSS 2 Marca Trevigiana, Neurology, Piazzale dell''Ospedale, 1, Treviso, IT 31100, Italy;11. Department of Neuroscience, Fatebenefratelli Hospital-Isola Tiberina, Rome, Italy;12. Neurology Unit, University Campus Bio-Medico of Rome, Rome, Italy |
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| Abstract: | Eighteen schizophrenic patients, 16 patients with idiopathic Parkinson's disease, and the same numbers of age, sex and education matched controls were examined with oddball experiments for the generation of P3. Individual averages were high-pass filtered at different cut-off frequencies with single-pole digital filters with equivalent analogue Butterworth filter profiles. The purpose of this procedure was to simulate analogue high-pass filters used in clinical studies from different centres and to examine their potential effect on group differences. Increasing high-pass filters resulted in a phase lead for all peaks examined (N1, P2, N2, P3). The only group differences were found for P3, which showed a greater phase lead in controls than in the patient groups, usually resulting in a more pronounced group difference. Similar wave forms and filter properties could be modelled by synthetic wave forms consisting of sine waves of different frequencies. |
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