Gallium-67-labelled red blood cells as a blood-pool marker for dual-isotope imaging |
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| Institution: | 1. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan;2. Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan;3. Department of Radiation Life Science and Radiation Medical Science, Kyoto University Research Reactor Institute, Osaka, Japan;4. Particle Radiation Oncology Research Center, Kyoto University Research Reactor Institute, Osaka, Japan |
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| Abstract: | Red blood cells were labelled with 67Ga oxine prepared from 67Ga citrate, a routinely available and relatively inexpensive radiopharmaceutical which is suitable for dual-isotope imaging with 99mTc. Labelling efficiency was 88 ± 1%, 24-h in vitro stability was 93 ± 5% in saline at room temperature and 68 ± 4% in whole blood at 37 °C, and the method could be performed within 20–30 min. |
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