Comparative effects of the polychlorinated biphenyl mixture,aroclor 1242, on porphyrin and xenobiotic metabolism in kidney of japanese quail and rat |
| |
| Affiliation: | 1. Department of Agricultural Chemistry, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, U.S.A.;1. Department of Poultry Science, Oregon State University, Corvallis, Oregon 97331, U.S.A. Tel. (503) 737-2363;1. College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China;2. Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China;3. Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, PR China;1. College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China;2. Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150086, PR China;3. Laboratory Animal Centre, Qiqihar Medical University, Qiqihar, 161006, PR China;4. Department of Physiology and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal, 8210, Bangladesh;5. Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China;6. Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, PR China;1. Institute of Chemistry, Slovak Academy of Sciences, Dubravska Cesta 9, 845 38 Bratislava, Slovakia;2. Glycanostics Ltd., Dubravska Cesta 9, 845 38 Bratislava, Slovakia;1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China;2. Department of Physiology and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal, 8210, Bangladesh;3. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, PR China;4. Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, PR China;1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China;2. College of Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, PR China;3. Laboratory Animal Center, Qiqihar Medical University, Qiqihar, 161006, PR China;4. Energy & Environmental Research Institute of Heilongjiang Province, Harbin, 150027, PR China;5. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, PR China;6. Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, PR China;1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China;2. College of Veterinary Medicine, Agricultural University of Hebei, Baoding, 071001, PR China;3. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, PR China;4. Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, PR China |
| |
| Abstract: | 1. Aroclor 1242 (500 mg/kg, p.o.) produced a marked increase in porphyrin content of quail kidney (1800-fold), and of rat kidney but to a lesser extent (6-fold).2. δ-Aminolevulinic acid synthetase activity was increased 12-fold in quail kidney but was unchanged in rat kidney folowing Aroclor 1242 treatment.3. Uroporphyrinogen decarboxylase activity was significantly inhibited in quail kidney but not in rat kidney.4. Renal ethoxyresorufin O-deethylase activity was induced in rat and quail whereas renal ethoxycoumarin O-deethylase and glutathione S-transferase activities were induced only in rats by Aroclor 1242. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
