Beauty and the yeast: compartmental organization of the secretory pathway |
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| Institution: | 1. Department of Pediatric Hematology, Hacettepe University, Ankara 06100, Turkey;2. Department of Toxicology, Gulhane Military Medical Academy, Ankara 06010, Turkey;3. Department of Pediatric Hematology, Gulhane Military Medical Academy, Ankara 06010, Turkey;4. Department of Biostatistics, Hacettepe University, Ankara, Turkey;1. Department of Microbiology, University of Delhi South Campus, New Delhi 110021, India;2. School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand;3. Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Corrensstr. 3, 06466 Gatersleben, Germany;1. School of Engineering, The University of Newcastle, Callaghan, Australia;2. The University of Thi-Qar, Nasiriya, Iraq;1. Instituto de Investigación e Ingeniería Ambiental and Escuela de Ciencia y Tecnología (UNSAM), Av. 25 de Mayo y Francia (C1650), San Martín, Buenos Aires, Argentina;2. CONICET, Argentina;3. Lab. Biológico-Lab. Química, INTI-Ambiente, Av. Gral Paz 5445 (B1650KNA), Buenos Aires, Argentina;4. Centro Atómico Bariloche - Complejo Tecnológico Pilcaniyeu, Comisión Nacional de Energía Atómica, Centro Atómico Bariloche, Av. E. Bustillo 9500 (8400), Bariloche, Rio Negro, Argentina;5. Universidad Tecnológica Nacional, Facultad Regional Buenos Aires, Extensión Áulica Bariloche, F.T. de Newbery 137 (8400), Bariloche, Rio Negro, Argentina |
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| Abstract: | Our perception of intracellular organelles and cellular architecture was initially based on striking light and electron micrographs of animal and plant cells. The high degree of compartmental organization within specalized mammalian secretory cells aided early efforts to track the movement of proteins through the organelles of the secretory pathway. In contrast, the morphological detail of the yeast Saccharomyces cerevisiae appeared superficially simple, even primitive, by comparison with the higher eukaryotic cells. However, the combination of genetic tools and the development of assays reconstituting vesicular traffic in yeast have facilitated the identification and characterization of individual proteins that function in the secretory pathway. Analogies between the function of yeast and mammalian proteins in vesicular traffic are being drawn with increasing frequency. In this review, the combination of genetic, biochemical, molecular and cell biological approaches used to study compartmental organization in the yeast secretory pathway will be discussed. The rapid progress in our understanding of yeast membrane traffic has revealed the beauty of working with this organism. |
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