Differential post-receptor responses of adenylate cyclase in white and brown adipose tissue membranes of rats fed high-energy diets |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, The City College of New York, New York, NY 10031, USA;2. Division of Chemical Biology and Medicinal Chemistry, The University of Texas, Austin, TX 78712, USA;3. The Graduate Center of The City University of New York (CUNY), New York, NY 10016, USA;1. Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden;2. Biomolecular Interaction Centre, Maurice Wilkins Centre for Biodiscovery, MacDiarmid Institute for Advanced Materials and Nanotechnology, Christchurch 8140, New Zealand;3. School of Biological Sciences, University of Canterbury, Christchurch 8140, New Zealand;4. Bio21 Molecular Science and Biotechnology Institute, Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia;5. Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia;6. Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia;7. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, VIC 3052, Australia;8. School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia |
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| Abstract: | - 1.1. Adenylate cyclase activity was determined in membranes of white and brown adipose tissue (WAT and BAT, respectively) from rats fed a high-energy diet (EXP group) vs those fed a nutritionally balanced one (CON group).
- 2.2. The isoproterenol- and guanine nucleotide-induced adenylate cyclase activity in WAT membranes of EXP rats was lower than that in CON rats.
- 3.3. Relative adenylate cyclase activity in like treated BAT membranes was higher in EXP than in CON rats.
- 4.4. It is concluded that feeding high-energy diets to rats induces similar post-receptor modifications of adenylate cyclase as found in genetic obese rodents.
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