Ciliary neurotrophic factor and its receptor complex |
| |
| Affiliation: | 1. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Yanagido1-1, Gifu 501-1193, Japan;2. Graduate School of Medicine, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan;3. Department of Functional Bioscience, Gifu University School of Medicine, Yanagido1-1, Gifu 501-1193, Japan;4. Kazusa DNA Research Institute, Kisarazu 293-0818, Japan;5. Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido1-1, Gifu 501-1193, Japan;1. Department of Orthopaedic Surgery, Brigham and Women''s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA;2. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA;3. Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA;4. Departments of Surgery and Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA;1. Department of Respiratory Diseases, Thoracic Disease Centre, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;2. Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China |
| |
| Abstract: | Ciliary neurotrophic factor (CNTF), originally identified for its ability to promote survival of neurons of the ciliary ganglion, is now known to have additional survival and differentiative actions on cells of the nervous system. CNTF is, however, unrelated in structure to the nerve growth factor family of neurotrophic factors. Instead, CNTF is distantly related to, and in fact shares receptor components with, a number of hemopoietic cytokines. This review focuses on the biological actions of CNTF, the shared and unique features of the CNTF receptor complex and signaling pathways, and the distribution of CNTF and its receptor during development, in the adult and in response to injury. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
