Selective localization of radioiodinated alkylphosphocholine derivatives in tumors |
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| Affiliation: | 1. Department of Physics, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway;2. Chemistry Department, Faculty of Science, Damietta University, New Damietta, Damietta, Egypt;3. Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway;1. Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, USA;2. Department of Haematology, Pathwest Laboratory Medicine WA and Sir Charles Gairdner Hospital, Nedlands;3. School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia;4. Department of Pharmacy;5. Department of Biostatistics;6. Department of Stem Cell Transplant and Cellular Therapies, The University of Texas MD Anderson Cancer Center, Houston, USA |
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| Abstract: | We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl-ammonium]ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors. |
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