Combined effect of vanadium and zinc on certain selected haematological indices in rats |
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| Institution: | 1. Laboratory of Inorganic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece;2. Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece;3. Institute of Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, N.C.S.R. “Demokritos”, Aghia Paraskevi 15310, Attiki, Greece;4. Division of Clinical and Molecular Endocrinology, 1st Department of Internal Medicine, AHEPA, University Hospital, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece;5. Center for Research of the Structure of Matter, Magnetic Resonance Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece;1. Center for Brain Computer Interfaces and Brain Information Processing, South China University of Technology, Guangzhou 510640, China;2. Guangzhou Key Laboratory of Brain Computer Interface and Applications (no. 15180006), Guangzhou 510640, China |
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| Abstract: | 1. Two-month-old Wistar rats of both sexes received, as sole drinking liquid, an aqueous solution of ammonium metavanadate (AMV) and zinc chloride (ZC) at concentrations of 0.30 mg V/cm3 and 0.12 mg Zn/cm3 respectively, for a period of 4 weeks.2. The reference groups received for drinking at this time: water, AMV or ZC solutions at the same concentration.3. In all groups of animals there was a statistically significant decrease in the uptake of food, AMV or ZC, as well AMV-ZC solutions, as compared with the food and water taken up by the control group.4. In the group of animals receiving AMV or AMV-ZC solution for drinking the body weight increment diminished significantly.5. In the animals drinking the AMV-ZC solution a statistically significant decrease in the erythrocyte count and haemoglobin level in the peripheral blood were recorded, similar to the groups drinking AMV or ZC solution.6. In rats drinking aqueous AMV or ZC solutions and in females receiving AMV-ZC solution the percentage of recticulocytes and polychromatophilic erythrocytes increased, moreover, in the peripheral blood. It was not, however, associated with marked percentage changes in the composition of the bone marrow cells. |
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