Complement-like protein from the phylogenetically primitive vertebrate,Eptatretus Stouti,is a Humoral Opsonin |
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| Institution: | Immunobiology Unit, School of Biological and Biomedical Sciences, University of Technology,SydneyP.O. Box 123, Broadway,N.S.W. 2007 Australia Tel. (02) 330 4096; Fax (02) 230 4095 |
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| Abstract: | - 1.1. Serum from the Pacific hagfish,Eptatretus stouti,contains a complement-like protein (CLP).
- 2.2. CLP from unfractionated hagfish serum and from affinity-purified preparations binds to yeast cell surfaces.
- 3.3. Incubation with CLP enhances the phagocytosis of yeast by hagfish leukocytes.
- 4.4. CLP-mediated opsonization can be inhibited by anti-CLP antibody, EDTA, d(+)mannose and l(+)rhamnose.
- 5.5. Additional opsomic factors are also in hagfish serum.
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