Characterization of postjunctional alpha-adrenoceptors in the isolated aorta of the snake Bothrops jararaca |
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| Affiliation: | 1. School of Business, Central South University, Changsha 410083, China;2. School of Mathematics and Statistics, Central South University, Changsha 410083, China;3. Institute of Metal Resources Strategy, Central South University, Changsha 410083, China;1. School of Qilu Transportation, Shandong University, 250002 Jinan, PR China;2. Shandong Hi-Speed Engineering Test CO., LTD, 250002 Jian, PR China;3. Suzhou Research Institute, Shandong University, 215021 Suzhou, PR China;4. Microlab, Faculty of Civil Engineering and Geosciences, Delft University of Technology, 2628 CN Delft, the Netherlands;1. Department of Psychiatry, University of California, San Diego, 8939 Villa La Jolla Drive, Suite 200, La Jolla, San Diego, CA 92037-0855, USA;2. Department of Physiological Sciences, University of Florida, Box 100144, 1333 Center Drive, Gainesville, FL 32610-0144, USA;3. Psychiatry Service, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA;1. Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi’an 710032, China;2. School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712000, China;1. School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab of Green Chemical Product Technology, South China University of Technology, Guangzhou 510641, China;2. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong, Sichuan 637000, China;3. Guangzhou Key Laboratory for New Energy and Green Catalysis, School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China |
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| Abstract: | 1. To characterize the alpha-adrenoceptors present in Bothrops jararaca aorta, selective alpha-adrenoceptor agonists and antagonists were used.2. The relative order of potency of the tested agonists was noradrenaline > phenylephrine > clonicline.3. Prazosin was more potent than phentolamine and yohimbine in antagonizing noradrenaline response, since the PA2 values were 9.91, 7.59 and 7.33, respectively.4. Yohimbine was also able to block the contraction produced by phenylephrine, an alpha-1 agonist.5. These results suggest the existence of an alpha-1 subtype of adrenoceptor in this preparation which, however, presents some different characteristics from those described for mammals. |
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