The agonist action of substituted phenylethanolamines on octopamine receptors in cockroach ventral nerve cords |
| |
| Affiliation: | 1. DISTAV, Department of Environmental Earth and Life Sciences, University of Genoa, Italy;2. National Biodiversity Future Center, Palermo, Italy;1. College of Marine Science, Guangxi Key Laboratory of Beibu Gulf Biodiversity Conservation, Beibu Gulf Ocean Development Research Centre, Beibu Gulf University, Qinzhou, Guangxi, China;2. Key Laboratory of Tropical Hydrobiology and Biotechnology of Hainan Province, Hainan Aquaculture Breeding Engineering Research Center, College of Marine Biology and Aquaculture, Hainan University, Haikou, Hainan 570228, China;3. Borneo Marine Research Institute, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia |
| |
| Abstract: | 1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana.2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA.3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase.4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone.5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
