Tetanus responses under rapid bath solution change: Electrotonic depolarization of transverse tubules may release Ca2+ from sarcoplasmic reticulum of Rana japonica skeletal muscle |
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Institution: | 1. Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, OK, USA;2. Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, OK, USA;3. Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;4. Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA;5. Oklahoma City VA Medical Center, Oklahoma City, OK, USA;6. Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, OK, USA;1. Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, 91400 Orsay, France;2. Inserm, UMR-S 999 « Hypertension pulmonaire: Physiopathologie et Innovation Thérapeutique », Hôpital Marie Lannelongue, Le Plessis-Robinson, France;3. Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France;4. Université Paris-Saclay, Inserm, CNRS, Ingénierie et Plateformes au Service de l''Innovation Thérapeutique-Plateforme MIPSIT, Orsay, France;1. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;2. Department of Neurobiology, Center for Neuroscience and Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA |
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Abstract: | - 1.1. Single skeletal muscle fibers were transferred from a normal Ringer solution to Na+ ion free solution, and vice versa, and tetanus responses were recorded immediately after the transfer.
- 2.2. Fractional tetanus tension recorded immediately after the displacement from the Na+ ion free solution to normal Ringer solution was dependent on fiber diameter.
- 3.3. Diffusion of Na+ ions along the transverse tubules was simulated apparent diffusion constant was 3.11 × 10−6 (cm2/s)].
- 4.4. Our results suggest that the electrotonic spreading of membrane potential, caused by an action potential in the transverse tubules, could release Ca2+ ions from sarcoplasmic reticulum.
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