Effects of FMRFamide-related peptides and morphine on the isolated foregut of the locust schistocerca gregaria |
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| Affiliation: | 1. Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 260, 8057 Zurich, Switzerland;2. Institute of Agricultural Sciences, ETH Zurich, Universitätstrasse 2, 8092 Zurich, Switzerland;3. Zoo Zurich, Zürichbergstrasse 221, 8044 Zürich, Switzerland;4. Leibniz Institute for Zoo and Wildlife Research (IZW), Alfred-Kowalke-Str. 17, 10315 Berlin, Germany;5. Zoological Gardens Wuppertal, Hubertusallee 30, 42117 Wuppertal, Germany;6. Jaderpark, Tiergartenstr. 69, 26349 Jaderberg, Germany;7. School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia;1. Department of Pathology, Louisiana State University Health Science Center, Shreveport, LA 71130, USA;2. Department of Otolaryngology, Louisiana State University Health Science Center, Shreveport, LA 71130, USA;1. Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan;2. Conservation and Research Department, Wildlife Reserves Singapore, Singapore;3. Leibniz Institute for Zoo and Wildlife Research (IZW), Berlin, Germany;4. ETH Zurich, Institute of Agricultural Sciences, Zurich, Switzerland;5. Department of Applied Mathematics, Research School of Physical Science and Engineering, The Australian National University, Canberra, Australia;6. Stichting Apenheul, Apeldoorn, The Netherlands;7. Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland |
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| Abstract: | 1. Morphine and YAGFMamide were the most effective potentiators of 5-hydroxytryptamine (5-HT)-induced relaxation of the isolated foregut.2. Morphine had no effect on proctolin-induced tissue contraction which was inhibited by YGGF-Mamide and YFMRFamide.3. The differing potency of FaRPs and morphine to potentiate 5-HT effects and reduce proctolin responses suggests that there are two separate FaRP receptor sub types.4. This proposal is supported by the observation that, while naloxone (10−5 M) is a relatively potent antagonist of FaRP induced inhibition of proctolin contraction, it has less effect on FaRP-induced potentiation of 5-HT-induced relaxation. |
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