A molecular model for the retinol binding protein-transthyretin complex |
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| Affiliation: | 1. Department of Molecular Biology, Uppsala University, Uppsala, Sweden;2. Department of Physical Chemistry, Uppsala University, Uppsala, Sweden;1. Department of Physics, University of Toronto, Toronto, Ontario, Canada;2. Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada;3. Department of Chemistry, University of Toronto, Toronto, Ontario, Canada;1. Institute of Physiology, Christian-Albrechts University, 24118 Kiel, Germany;2. Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany;3. Leibniz-Institut für Molekulare Pharmakologie, 13125 Berlin, Germany;4. Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK;5. OXION Initiative, University of Oxford, Oxford OX1 3PU, UK;6. Nanion Technologies GmbH, 80636 Munich, Germany;1. Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts;1. Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK;2. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK;3. OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK;4. Department of Physiology, University of Kiel, 24118 Kiel, Germany;5. Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK;1. Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA;2. Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA;3. Biophysics Graduate Program, University of California Berkeley, Berkeley, CA 94720, USA;4. California Institute for Quantitative Biology (QB3), University of California Berkeley, Berkeley, CA 94720, USA |
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| Abstract: | A three-dimensional model for the complex between human serum retinol binding protein and transthyretin (formerly named prealbumin) is presented. The model was obtained by interactive rigid-body computer graphics docking and the characterization of the molecular surfaces in terms of fractal dimension. Available experimental data, as well as results from molecular dynamics calculations, support the proposed model. |
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