On metallothionein,cadmium, copper and zinc relationships in the liver and kidney of adult rats |
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| Institution: | 1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt;2. Department of Zoology, Faculty of Science, Al-Azhar University, Egypt;3. Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, 62514, Beni-Suef, Egypt;1. Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt;2. Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt;3. Department of Biochemistry, Faculty of Medicine, Minia University, Minia, Egypt;1. Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea;2. Department of Food Science and Technology, Kongju National University, Yesan, Choongnam, Republic of Korea;3. College of Pharmacy, Pusan National University, Busan, Republic of Korea;4. Graduate Department of Chemical Materials, Pusan National University, Busan, Republic of Korea;1. Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan;2. Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan;3. Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, Japan;1. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia;2. Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt;3. Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt |
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| Abstract: | 1. A short-term exposure of adult Wistar rats to Cu (50 μg/ml) and Cd (10.0 μg/ml drinking water) caused significant changes in the subcellular concentrations of Cd, Cu, Zn and metallothionein (MT) in the liver and kidney; the concentrations were close to the physiological values, however.2. To establish a relationship between these changes in the subcellular concentrations of Cd, Cu, Zn and the level of MT in the post-mitochondrial fraction of the liver and kidney, the analytical data (N = 42) were subjected to the multiple regression analysis.3. The analysis showed that MT synthesis in the liver was principally induced by small amounts of Cd (0.32–1.4 μg/g wet wt) whereas in the kidney a level of MT in the post-mitochondrial fraction correlated positively with the renal Cd and Cu, as well as with the level of this protein in the liver.4. The above results together with the positive correlation between the level of MT in the post-mitochondrial fraction and the concentration of Cu in this fraction, as well as the fact that under normal physiological conditions the capacity of MT (β-domain) in the liver and kidney was sufficient to bind 50–100% of the total post-mitochondrial Cu suggest that MT, first induced by small amounts of Cd, may be involved in the metabolism of Cu. |
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