Neutral amino acid transport in an androgen-dependent epithelium |
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Affiliation: | Cell and Developmental Biology Research Unit, School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand. Tel.: 644-721-000; Fax: 644-712-070 |
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Abstract: | - 1.1. Transport of neutral amino acids by the isolated seminal vesicle epithelium of normal and gonadectomized guinea pigs has been investigated by measurement of the uptake of 2-amino[1-14C]-isobutyric acid and 2-methylamino[1-14C]isobutyric acid.
- 2.2. The Vmax for Na-dependent and -independent transport of both amino acids was reduced by gonadectomy but the general transport characteristics appeared to be unchanged by this treatment.
- 3.3. The most likely explanation of the decreased transport is the loss of transporter molecules associated with the tissue regression that follows rapidly on gonadectomy.
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