Event-related neuronal responses in the human strio-pallido-thalamic system. I. Sensory and motor functions |
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| Affiliation: | 1. Institute of Materials Chemistry, University of Vienna, Währingerstrasse 42, Wien A-1090, Austria;2. Institute of Solid State Physics, TU-Wien, Wiedner Hauptstrasse 8-10, Wien A-1040, Austria;3. Christian Doppler Laboratory for Thermoelectricity, Wien, Austria;4. Thermoelectric Materials and Devices Laboratory, Department of Physics, Indian Institute of Science, Bangalore 560 012, India;5. Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Science, 110016 Shenyang, Liaoning, People''s Republic of China;6. School of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, People''s Republic of China;7. Institute of Physics of Materials, Czech Academy of Sciences, Žižkova 22, Brno 61662, Czech Republic;8. Physics of Nanostructured Materials, University of Vienna, Boltzmanngasse 5, Wien A-1090, Austria;1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States;2. School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, United States;3. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States;4. Laboratory of Brain and Cognition, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada;5. Departments of Psychiatry and Psychology, McGill University, Montreal, QC, Canada;6. Douglas Hospital Research Centre, Montreal, QC, Canada;7. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada |
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| Abstract: | Multiunit activity was recorded from strio-pallido-thalamic sites in parkinsonian patients bearing gold electrodes for diagnosis and therapy. The patients voluntarily participated in tasks designed to study neuronal correlates of both physical and semantic characteristics of stimuli as well as motor responses. Six modifications of the stimulus-response paradigm were used: visual odd-ball, visual and acoustic odd-ball tasks; tasks in which either the stimulus intensity or the meaning of non-target stimuli varied; single-stage delayed response and dual-stage delayed response tasks, respectively. In each task the patients had to evaluate some of the stimulus characteristics and to respond in a particular way according to the preliminary instructions. Peristimulus time histograms for each multiunit separately as well as profiles of reactions and profiles of reaction differences for the whole set of multiunits were calculated and subjected to statistical analysis. Two functional groups of subcortical neuronal reactions, stimulus-related and response-related activities, were separated. The stimulus-related activities of most multiunits were modality-unspecific. Their most striking feature was dependence on stimulus relevance and also its probability, the strongest reactions observed in response to task relevant stimuli occurring with low probability. The response-related activities occurred prior to initiation of movements, dependent upon the particular action and its probability. The data suggest at least two different and spatially overlapping subcortical channels responsible for goal-directed behaviour: the one related to stimulus assessment and the other to preparation for motor action. |
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