Increased incidence of disomic sperm nuclei in a 47,XYY male assessed by fluorescent in situ hybridization (FISH) |
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| Authors: | Joan Blanco Carmen Rubio Carlos Simon Josep Egozcue F. Vidal |
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| Affiliation: | (1) Unitat de Biologia Cellular, Facultat de Ciències, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain Tel.: +34-3-581-27-81; Fax: +34-3-581-22-95, ES;(2) Instituto Valenciano de Infertilidad, Valencia, Spain, ES;(3) Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain, ES |
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| Abstract: | Using triple-colour fluorescent in situ hybridization in decondensed sperm heads, we assessed the sex-chromosome distribution in spermatozoa from a 47,XYY male compared with controls. The incidence of spermatozoa with 24,XY (0.30%) and 24,YY (1.01%) disomy was significantly higher than in our control series. Diploid meiocytes present in the ejaculate were mainly 47,XYY (60.6–86.7%), and haploid meiocytes were mainly 24,XY (78.1%).These results suggest that, although the extra Y chromosome is thought to be eliminated during spermatogenesis, XYY germ cells can complete meiosis and produce disomic spermatozoa. Received: 5 August 1996 / Revised: 2 October 1996 |
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