The Analgesic Effect and Mechanism of the Combination of Sodium ferulate and Oxymatrine |
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Authors: | Hanqing Liu Yan Sun Yan Gao Fangfang Chen MingBo Xu Zhifeng Liu |
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Institution: | (1) School of Pharmacy, Yantai University, No. 30, Qingquan Road, 264005 Laishan District, Yantai, Shandong, China;(2) Beijing SL Pharmaceutical Co., Ltd, No. 9, Shijingshan Industrial Area, 100037 Haidian District, Beijing, China; |
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Abstract: | Sodium ferulate (SF) and Oxymatrine (OMT) were compounds extracted from Chinese herbs, and have been used in clinical treatment
of heart and hepatic diseases, respectively, in China for many years. The objective of this study was to examine the analgesic
effect and the mechanism of the combined treatment of SF and OMT. Using the animal pain models by applying Acetic Acid Writhing
Test and Formalin Test, the combination of SF and OMT showed significant analgesic effect in dose-dependent manner. In vitro,
the combined treatment inhibited the increase in intracellular calcium concentration evoked by capsaicin in the dorsal root
ganglion neurons. Importantly, a synergistic inhibitory effect of SF and OMT on the capsaicin-induced currents was demonstrated
by whole-cell patch-clamp. Our results suggest that SF and OMT cause significant analgesic effect which maybe related to the
synergistic inhibition of transient receptor potential vanilloid-1. |
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Keywords: | |
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