Analysis of the role of PCNA-DNA contacts during clamp loading |
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| Authors: | Randall McNally Gregory D Bowman Eric R Goedken Mike O'Donnell John Kuriyan |
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| Affiliation: | (1) Department of Molecular and Cell Biology, Department of Chemistry, California Institute for Quantitative Biosciences (QB3), Howard Hughes Medical Institute, University of California, Berkeley, 94720 Berkeley, CA, USA;(2) Physical Biosciences Division, Lawrence Berkeley National Laboratory, 94720 Berkeley, CA, USA;(3) Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, Box 228, 10021 New York, NY, USA;(4) Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, 21218-2685 Baltimore, MD, USA;(5) Abbott Bioresearch Center, 100 Research Drive, 01605 Worcester, MA, USA |
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| Abstract: | Background Sliding clamps, such as Proliferating Cell Nuclear Antigen (PCNA) in eukaryotes, are ring-shaped protein complexes that encircle DNA and enable highly processive DNA replication by serving as docking sites for DNA polymerases. In an ATP-dependent reaction, clamp loader complexes, such as the Replication Factor-C (RFC) complex in eukaryotes, open the clamp and load it around primer-template DNA. |
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