Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet |
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Authors: | Yokogoshi H Oda H |
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Institution: | (1) School of Food and Nutritional Sciences, The University of Shizuoka, Shizuoka, Japan, JP;(2) Department of Applied Biological Sciences, Nagoya University, Nagoya, Japan, JP |
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Abstract: | Summary. The effect of taurine on hypercholesterolemia induced by feeding a high-cholesterol (HC) diet (10 g/kg) to rats was examined.
When taurine was supplemented to HC for 2 wk, serum total cholesterol significantly decreased and serum HDL-cholesterol increased
compared with the HC diet group. In the hypercholesterolemic rats fed the HC diet, the excretion of fecal bile acids and hepatic
cholesterol 7α-hydroxylase (CYP7A1) activity and its mRNA level increased significantly, and the supplementation of taurine further enhanced
these indexes, indicating an increase in cholesterol degradation. Agarose gel electrophoresis revealed that, in hypercholesterolemic
rats fed the HC diet, the serum level of the heavier VLDL increased significantly, but taurine repressed this increase and
normalized this pattern. Significant correlations were observed between the time-dependent increase of CYP7A1 gene expression
and the decrease of blood cholesterol concentration in rats fed the HC diet supplemented with taurine. These results suggest
that the hypocholesterolemic effects of taurine observed in the hypocholesterolemic rats fed the HC diet were mainly due to
the enhancement of cholesterol degradation and the excretion of bile acid.
Received December 4, 2001 Accepted January 2, 2002 Published online September 10, 2002
Acknowledgment This work was supported by a grant of Taisho Pharmaceutical Co., Ltd (Japan). We thank J. I. Gordon for their generous gifts
of cDNAs.
Authors' address: Dr. Hidehiko Yokogoshi, School of Food and Nutritional Sciences, The University of Shizuoka, Shizuoka 4228526, Japan, E-mail:
yokogosi@u-shizuoka-ken.ac.jp |
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Keywords: | : Taurine Cholesterol Hypocholesterolemia Cholesterol 7α -hydroxylase (CYP7A1) Rat |
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