Quantitative trait loci from the host genetic background modulate the durability of a
resistance gene: a rational basis for sustainable resistance breeding in plants |
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Authors: | J Quenouille E Paulhiac B Moury A Palloix |
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Institution: | 1.INRA, UR1052 GAFL, Montfavet Cedex, France;2.INRA, UR407 Pathologie
Végétale, Montfavet Cedex, France |
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Abstract: | The combination of major resistance genes with quantitative resistance factors is
hypothesized as a promising breeding strategy to preserve the durability of resistant
cultivar, as recently observed in different pathosystems. Using the pepper (Capsicum
annuum)/Potato virus Y (PVY, genus Potyvirus) pathosystem, we
aimed at identifying plant genetic factors directly affecting the frequency of virus
adaptation to the major resistance gene pvr23 and at
comparing them with genetic factors affecting quantitative resistance. The resistance
breakdown frequency was a highly heritable trait (h2=0.87).
Four loci including additive quantitative trait loci (QTLs) and epistatic interactions
explained together 70% of the variance of pvr23
breakdown frequency. Three of the four QTLs controlling pvr23
breakdown frequency were also involved in quantitative resistance, strongly suggesting
that QTLs controlling quantitative resistance have a pleiotropic effect on the durability
of the major resistance gene. With the first mapping of QTLs directly affecting resistance
durability, this study provides a rationale for sustainable resistance breeding.
Surprisingly, a genetic trade-off was observed between the durability of PVY resistance
controlled by pvr23 and the spectrum of the resistance
against different potyviruses. This trade-off seemed to have been resolved by the
combination of minor-effect durability QTLs under long-term farmer selection. |
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