Association of Saccade Duration and Saccade Acceleration/Deceleration Asymmetry during Visually Guided Saccade in Schizophrenia Patients |
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| Authors: | Hong Cui Xiao-hui Liu Ke-yong Wang Chun-yan Zhu Chen Wang Xin-hui Xie |
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| Institution: | 1. Division of Medical Psychology, Chinese PLA General Hospital and Medical School PLA, Beijing, China.; 2. Department of Psychiatry, Anhui Mental Health Center, Hefei, Anhui, China.; 3. Department of Medical Psychology, Anhui Medical University, Hefei, Anhui, China.; Institute of Psychology, Chinese Academy of Sciences, China, |
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| Abstract: | ObjectiveTo examine the difference between schizophrenia patients and normal controls on velocity and acceleration of saccade, by using the basic visually guided saccade (VGS) paradigm.MethodsEighteen schizophrenia outpatients and fourteen normal controls participated in the VGS task. Multiple indicators, including amplitude, duration, velocity, latency, accuracy rate, acceleration, and deceleration were analyzed. Asymmetric acceleration index (AAI) was introduced to describe the difference between peak acceleration and peak deceleration. The correlation coefficient (RAD) of AAI and duration was computed to examine the difference between schizophrenia patients and normal controls.ResultsNo significant difference between patients and normal controls was found on amplitude, duration, latency, and accuracy rate. However, RAD values of schizophrenia patients were significantly lower than the control group.ConclusionCompared to normal controls, association of saccade duration and saccade acceleration/deceleration asymmetry during visually guided saccade was lower in schizophrenia patients. |
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