Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint |
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| Authors: | B Halliwell M Wasil M Grootveld |
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| Affiliation: | Department of Biochemistry, King''s College (KQC), Strand Campus, London WC2R 2LS, England |
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| Abstract: | Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage. |
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