20-羟二十烷四烯酸在机体生理及病理调节中的作用

20多年前,国外学者就报道了机体内某些组织中存在着细胞色素P-450（cytochrome P-450,CYP）。已经证实它能催化花生四烯酸（arachidonic acid,AA）的ω-羟基生成20-羟二十烷四烯酸（20-hydroxyeicosatetraenoic acid,20-HETE）。随着研究的不断深入,人们逐渐发现作为第二信使,20-HETE在调节血管平滑肌紧张度、肾功能、脑血流量和肺血管舒张过程中发挥了重要作用;外源性的20-HETE对心脏冠脉循环也有明显的调节作用;并且它与高血压和妊娠毒血症等疾病的发生和发展关系密切。但国内对于20-HETE的相关研究还鲜有报道,本文将主要就20-HETE在机体生理及病理及病理调节中的作用作一综述。

Roles of 20-HETE on physiologic and pathologic regulation in organism

Twenty years ago, some foreign-investigators reported that omega-hydroxylation of arachidonic acid (AA) was catalyzed by cytochrome P-450 enzymes in some tissue to 20-hydroxyeicosatetraenoic acid (20-HETE). As a second messenger, it plays a pivotal role in the regulation of vascular tone, renal function, cerebral blood flow and lung vasodilator. Exogenous administeration of 20-HETE also plays an important role in the regulation of the coronary circulation. Moreover, hypertension, toxemia of pregnancy and other diseases is related to the formation of the 20-HETE. However, there is few domestic report about 20-HETE. Therefore, the domestic investigators should be given attention to 20-HETE adequately in the future. In this paper, roles of 20-HETE on physiologic and pathologic regulation in organism were reviewed.