Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeast |
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| Authors: | Igor A Valouev Gleb V Fominov Elizaveta E Sokolova Vladimir N Smirnov Michael D Ter-Avanesyan |
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| Affiliation: | (1) Cardiology Research Center, 121552 Moscow, Russia |
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| Abstract: | Background Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRF1 and eRF3. While eRF1 recognizes nonsense codons, eRF3 facilitates polypeptide chain release from the ribosome in a GTP-dependent manner. Besides termination, both release factors have essential, but poorly characterized functions outside of translation. |
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