Nature meets nurture: molecular genetics of gastric cancer |
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| Authors: | Anya N Milne F Carneiro C O’Morain G J A Offerhaus |
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| Institution: | 1.Pathology Department H04.2.25,University Medical Centre Utrecht,Utrecht,The Netherlands;2.Institute of Molecular Pathology and Immunology,University of Porto (IPATIMUP),Porto,Portugal;3.Medical Faculty,Hospital S. Jo?o,Porto,Portugal;4.Department of Gastroenterology,Adelaide and Meath Hospital,Dublin,Ireland;5.Department of Pathology,Academic Medical Centre,Amsterdam,The Netherlands |
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| Abstract: | The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming and the relevant importance of some
of these molecules is too often unclear. This review serves to bring us up-to-date with the latest findings as well as to
look at the larger picture in terms of how to tackle the problem of solving this multi-piece puzzle. In this review, the environmental
nurturing of intestinal cancer is discussed, beginning with epidemiology (known causative factors for inducing molecular change),
an update of H. pylori research, including the role of inflammation and stem cells in premalignant lesions. The role of E-cadherin in the nature
(genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed. |
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