Differential Roles of Raphe Nuclei in the Regulation of Dopamine β-Hydroxylase in the Adrenal Gland of the Rat |
| |
| Authors: | L. Lima T. L. Sourkes B. Dubrovsky |
| |
| Affiliation: | Departments of Biochemistry and Psychiatry, McGill University, Montreal, Quebec, Canada |
| |
| Abstract: | The effect of reserpine on the activity of dopamine beta-hydroxylase (DBH) in the adrenal gland of the rat was determined following electrolytic lesion of the dorsal raphe nucleus (DRN) or medial raphe nucleus (MRN). In sham-operated rats, as well as in those with a lesion of the DRN, there was no significant modification of the action of reserpine on this enzyme. However, a lesion of MRN potentiated the inducing action of the drug. A specific role of MRN in the serotonergic regulation of adrenal DBH is suggested by this work. |
| |
| Keywords: | Adrenal gland Dopamine β-hydroxylase Dorsal raphe nucleus Medial raphe nucleus Reserpine |
|
|
