Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases |
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| Authors: | Hirschey Matthew D |
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| Affiliation: | 1Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA;2Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA;3Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA |
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| Abstract: | Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins. |
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